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RESEARCH PAPER / 2025-10-20

Hearing Health in Home Healthcare: Leveraging LLMs for Illness Scoring and ALMs for Vocal Biomarker Extraction

Yu-Wen Chen, William Ho, Sasha M. Vergez ...Full author list in the original paper.

Columbia University +4 · The Second Workshop on GenAI for Health at NeurIPS 2025

Affiliations: Columbia University, Department of Computer Science, Department of Electrical Engineering, School of Nursing, The Fu Foundation School of Engineering and Applied Science

Abstract

The growing demand for home healthcare calls for tools that can support care delivery. In this study, we explore automatic health assessment from voice using real-world home care visit data, leveraging the diverse patient information it contains. First, we utilize Large Language Models (LLMs) to integrate Subjective, Objective, Assessment, and Plan (SOAP) notes derived from unstructured audio transcripts and structured vital signs into a holistic illness score that reflects a patient's overall health. This compact representation facilitates cross-visit health status comparisons and downstream analysis. Next, we design a multi-stage preprocessing pipeline to extract short speech segments from target speakers in home care recordings for acoustic analysis. We then employ an Audio Language Model (ALM) to produce plain-language descriptions of vocal biomarkers and examine their association with individuals' health status. Our experimental results benchmark both commercial and open-source LLMs in estimating illness scores, demonstrating their alignment with actual clinical outcomes, and revealing that SOAP notes are substantially more informative than vital signs. Building on the illness scores, we provide the first evidence that ALMs can identify health-related acoustic patterns from home care recordings and present them in a human-readable form. Together, these findings highlight the potential of LLMs and ALMs to harness heterogeneous in-home visit data for better patient monitoring and care.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

This study presents a pioneering approach to health assessment by leveraging LLMs and ALMs to analyze vocal biomarkers from home healthcare data. The innovative methodology and promising results indicate a significant step forward in the application of AI in healthcare, although further work is needed to address reproducibility and implementation challenges.

Methodology

The methodology presented in this paper is robust, combining LLMs and ALMs to create a novel framework for health assessment based on vocal biomarkers. The integration of SOAP notes and vital signs into a unified illness score is innovative, allowing for a more holistic view of patient health. The multi-stage preprocessing pipeline for acoustic analysis is well-designed, addressing challenges inherent in real-world data collection. However, the reliance on LLMs for generating SOAP notes and illness scores raises questions about potential biases in the model outputs and the interpretability of the generated scores.

Results & evaluation

The experimental evaluation is thorough, with a clear focus on benchmarking various LLMs and ALMs. The use of real-world home care visit data adds significant value, as it reflects authentic patient-clinician interactions. The results demonstrate that LLM-generated illness scores align well with clinical outcomes, providing evidence of the method's effectiveness. However, the paper could benefit from more detailed statistical analysis and comparisons with traditional health assessment methods to strengthen the claims made.

Reproducibility

The paper provides a comprehensive overview of the models and methods used, including specific LLMs and ALMs. However, it lacks detailed information on the implementation and access to the datasets, which may hinder reproducibility. The absence of a publicly accessible code repository or demo further limits the ability for others to replicate the study.

Limitations

The study acknowledges several limitations, including the challenges of background noise and speaker overlap in real-world recordings. Additionally, the focus on the first 30 seconds of speech may overlook important acoustic cues that could emerge later in the conversation. The potential for LLMs to rely on contextual information rather than purely acoustic signals is another concern that warrants further investigation.

Broader impact

This research has significant implications for the future of home healthcare, particularly in enhancing patient monitoring through voice analysis. The findings suggest that vocal biomarkers can serve as valuable supplementary indicators of health status, which could lead to more timely interventions and improved patient outcomes. The approach also highlights the potential for integrating AI technologies into clinical practice, paving the way for more personalized and efficient healthcare solutions. This study presents a pioneering approach to health assessment by leveraging LLMs and ALMs to analyze vocal biomarkers from home healthcare data. The innovative methodology and promising results indicate a significant step forward in the application of AI in healthcare, although further work is needed to address reproducibility and implementation challenges.

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